Liver Type Fatty Acid Binding Protein (L-FABP): A Marker of Contrast Induced -Acute Kidney Injury

Abstract

Background: Urinary Liver type fatty acid binding protein (L-FABP) is an early biomarker for renal damage. A few studies have been published analyzing the potential use of urinary Liver type fatty acid binding protein (L-FABP) as a biomarker for acute kidney injury. However no study has been done related to Acute Kidney Injury associated with contrast administration.

Aim: To search for new markers to identify Acute Kidney Injury (AKI) associated with contrast administration earlier than serum creatinine.

Material and Methods: We studied 100 consecutive patients with normal serum creatinine undergoing angiographic procedure. We assessed urinary liver type fatty acid binding protein (L-FABP) levels at basal, 2h 4h, 12h, 24 h and 48 hours after the angiographic procedure. Serum creatinine was measured at basal, 24h and 48 hours after the procedure.

Results: There was a significant rise in urinary L-FABP levels at 12 hours after the angiographic procedure. The presence of contrast induced nephropathy associated with acute Kidney Injury was 9%.

Conclusion: The present study highlighted the importance of urinary L-FABP in detecting Acute Kidney Injury associated with contrast administration earlier than Serum creatinine.

Keywords: Liver type fatty acid binding protein (L-FABP).   Glomerular Filtration Rate (GFR), Contrast induced acute kidney injury (CI-AKI).