Role of Leukotriene in Gastric Ulcer Induced by Acetyl Salicylic Acid in Male Rabbits : Gastroprotection by Montelukast

Abstract

Gastric mucosal damage is a common disorder of the gastrointestinal system. Non- steroidal anti-inflammatory drugs (NSAID) are known to be aggressive agents for gastric ulcer development. Leukotrienes  play an important role in gastric mucosal damage induced by NSAIDs. Montelukast , a selective reversible Cysteinyl leukotriene receptor 1 antagonist, was reported to have beneficial effects in management of experimental gastric mucosal ulceration. This study designed to evaluate  the role of leukotriene against acetyl salicylic acid-induced gastric mucosal damage and to evaluate the gastroprotective activity of montelukast . Thirty local domestic male rabbits had been used in this study , divided into five groups as follows: normal control group, acetylsalicylic acid ( ASA) treated group, Omeprazole pretreatment group, montelukast pretreatment group, montelukast alone  treatment group. At the end of the experiment, the stomach of rabbit  is removed to prepare the tissue homogenate .  The results revealed that after administration of ASA significantly increase the mean ulcer index along with the LTD4 concentration, LTB4 concentration . But in presence of  montelukast  there is a significant decreased in the mean ulcer index along with  LTD4 concentration, LTB4 concentration .  These results suggest that the leukotrienes play an important role in  acetyl salicylic acid induced gastric ulcerations and gastroprotective activity of montelukast can be attributed to decreased activity of leukotrienes in gastric mucosa .

Keywords :  Gastric ulcer , H.pylori , Non-steroidal anti-inflammatory drugs , montelukast