The Genetic Association between Baldness, Coronary Heart Diseases and ABO Blood Group System in Men in Baqubah City-Diyala Province in Iraq

Abstract

Background and objectives: Coronary heart disease (CHD) is a major cause of death and disability worldwide. This study designed to determine the correlation of ABO histo-blood groups with baldness and susceptibility to cardiac diseases in Baqubah city, Diyala province in Iraq .Patients and methods: In this cross sectional, hospital based case control study, 68 male were enrolled .Group (A) include 34 males with CHD, ages ranged ( 45 – 55) year old. Group (B), include 34 healthy males, age range (45 – 55) years old. Coronary artery diseases diagnosis based on laboratory investigation of complete lipid profile analysis(LDL, triglyceride, HDL),Echocardiography and history of cardiac catheterization .ABO Histo-blood groups determined using commercial kits. Results: In healthy men , the ratio of individuals with normal hair to bald one was 1:1 . Regarding to patients group, 32% of CHD patient with normal hair and 68% bald with statistical significant difference (p ? 0.01). The frequency distribution of blood group type O between healthy people and CHD patients was 50% and 62%, respectively, and the difference was statistically significant (p ? 0.05).The frequency of histo-blood group of B type within bald healthy group was more than that reported in patients with normal hair. On the contrary, the frequency of histo-blood group of O type reported among patient with normal hair than bald CHD with statistical significant difference (p ? 0.05).Conclusion: people with hereditary baldness may have a predisposition to heart disease compared with people with natural hair. Blood groups distribution may affect indirectly on rates of heart disease difference Keywords: Coronary heart disease; ABO blood group; Baldness, Iraq