Abnormalities of Hormones and Inflammatory Cytokines in Women Affected With Polycystic Ovary Syndrome

Abstract

Polycystic ovary syndrome (PCOS) is a common hormone disorder of women. Women with PCOs have difficulty to pregnat and have a high levels of  androgens with oligomenorrhea, hirsutism, and obesity.

The present study was designed to investigate of some hormones and inflammatory markers of women with PCOS, Their ages ranged between 23-24 years old. Means of luteal hormone (LH) , testosterone, Insulin, and Homeostasis model assessment (HOMA-IR) were significantly (p<0.05) higher in women with PCOs when compared with control women. Concerning means of follicle stimulating hormone (FSH) and estradiol hormone were insignificant different (p>0.05) in affected women with PCOs in acomparison with control. Regarding means of inflammatory cytokines including C- Reactive proteins (CRP), interleukin- 6 (IL-6), and leptin have been showed a significant increase (p<0.05) in women with PCOS in a comparison with healthy control women. Data obtained from the present study indicate that women with PCOS have hormones disturbances associated with insnlin resistance and elevated levels of inflammatory cytokines may be in turn aggravate infertility of women with PCOS.

Keywords: Polycystic ovary syndrome, insulin resistance, obesity, infertility.