Splenotoxic Potentials of Chloroquine, Fansidar, Cotecxin and Amalar

Abstract

The Histologic studies on the spleen was carried out with Chloroquine, Fansidar, Cotecxin and Amalar to observe any pathologic effect(s) on the tissue on comparative basis. The study revealed some degenerated white pulps and wider interstitial spaces with chloroquine drug not observed in control samples. Also animals with fansidar administration showed clumping of periateriolar lymphoid cells in the white pulp not shown in the control group without any drug. In the Amalar group the spleen showed sinuisoidal dilation in the red pulp with macrophages scattered around it but not in the form of activation. For cotecxin drug there was the degeneration of periarteriolar lymphoid sheaths with residue of the infiltrated cells in the arterioles. It is concluded that chloroquine, fansidar, cotecxin may induce jaundice and splenic disorders.

Keywords: splenomegaly, splenic rupture, anti-malaria drugs.