Study the Correlation of the Leptin to Adiponectin Ratio with Estimation of Insulin Resistance in Obese and Non Obese Individuals

Abstract

Background: Leptin to Adiponctin ratio (LAR) has been reported as potentially useful measure of insulin resistance (IR). Obesity is the dominant cause of insulin resistance. The concentration of leptin rises with obesity, whereas that of adiponectin decreases with obesity. We investigated whether LAR may serve as a better predictor than either leptin or adiponectin alone for (IR) and study the correlation between LAR and insulin in obese individuals.Subjects and methods: this study included 90 non-diabetic Iraqi males (45 obese with mean age (39.80±8.10) years old, range from (30-55) year and 45 non-obese individuals with mean age (42.0±7.04) years old, range from (31-54) year. Leptin, adiponectin and insulin were measured using enzyme linked immunosorbent assay technique (ELISA).Results: LAR, IR and leptin show significant highly increased in obese group compared to non-obese healthy subjects, while Adiponectin level show significant high decreased in obese group. The pearson correlation analysis found LAR had strong significant positive correlation with leptin (r= 0.400, p<0.007) and strong significant negative correlation with adiponectin (r= -0.78, p<0.00).   Conclusion: the leptin-to-adiponectin ratio (LAR) correlates with insulin resistance better than either leptin or adiponectin levels alone.

Keywords: Lar, Ir, Leptin, Adiponectin and Obeaity.