Effect of Arabidopsis extracts on the Status of Liver Histology of Alloxan-induced Diabetic Mice

Abstract

Arabidopsis is a member of the Brassicaceae family, which includes important crops. It has no agronomic significance, but offers important advantages for basic research in genetics and molecular biology . Insulin-like growth factor 1 (IGF-1), known as “somatomedin C”,” found in Arabidopsis thaliana seeds. Anti-diabetic medical plants are general known to exert their beneficial effects on diabetes via various modes and mechanism depending on the phytochemicals and bioactive agents endowed in such plants.

In this study the Arabidopsis thaliana ethanolic seed extract has hyperglycemic. In conclusion, the present results showed that Arabidopsis consumption reversed most of the histological changes in the diabetic mice. This effect was due to the hypoglycemic effect of the Arabidopsis and improving the insulin resistance. In addition, in diabetes there was an increase in the oxidative stress which was significantly reduced by Arabidopsis consumption owing to its antioxidant effect.

Key words: Arabidopsis thaliana, Brassicaceae family, ethanolic seed extract, Insulin-like, hyperglycemic.