Neurotoxic Effect of Oseltamivir Phosphate Directly Dosed To Mice Pups during Lactation Period

Abstract

This study was performed  to detect any behavioral or brain histological changes may be  related to oseltamivir .phosphate. .administration.in.mice pups.The neurotoxic effects of oseltamivir phosphate in mice pups  was evaluated  by the  results  of selected  neurobehavioral tests and histopathological lesions that observed  in the brains of treated animals by  direct   daily oral drug administration  for  the last fourteen days of lactation period ,the study began when pups reached 7 days of  age. The experimental groups consist of three treated groups T1,T2,T3 were given  the dose 2.5, 7.5 and 25 mg/kg B.W of oseltamivir phosphate orderly while control group treated with distilled water. The results of performed neurobehavioral test which including  open field test, head pocking , cleft avoidance ,swimming rank, righting reflex  and negative geotaxis tests indicated clearly presence of  behavioral changes of treated animals and this results are supported by histological lesions of brain which observed a dose dependent manner effect, even at therapeutic dose.These   results probably were attributed to the change of the level of CNS neurotransmitters  or due to brain lesions may be caused by the drug which may affect the release of these neurotransmitters accordingly with  oseltamivr phosphate dose.

Keywords:oseltamivir phosphate, neurobehavioral ,neurotransmitters, toxic effect