Hypoglycemic Action of Synergistic Interaction of Phenolic Compounds Isolated from Iraqi Phoenix dactylifera (Breim) Leaflets in Alloxan – Induced Diabetic Rabbits

Abstract

Diabetes mellitus is a multifactorial disorder characterized by hyperglycemia resulting from increased hepatic glucose production . The current study was carried out to investigate the hypoglycemic action of synergistic interaction of phenolic compounds isolated from Iraqi Phoenix dactylifera (Breim) leaflets . Infra - red and gas chromatography – mass spectroscopies were applied for identification of the phenolic compounds which are represented by alpha – tocopherol , 2-hydroxy-5-methylisophthalaldehyde , 3-hydroxy –tyrosine and 4-n-propylresorcinol . The phenolic compounds recorded a significant decreasing after 4 hours ( 280.1 mg / 100 ml ) and highly significant decreasing at 6 hours ( 238.3 mg/ 100 ml ) and 24 hours ( 134.5.mg / 100 ml ) after oral administration in hyperglycemic rabbits . The phenolic compounds had no toxic effect on red blood cells since no hemolysis was found towards these cells, this means phenols Isolated can be used safely to treat diabetes mellitus disease instead of insulin drug but this work demands further clinical and pharmaceutical studies .

Keywords:Phoenix dactylifera (Breim) , phenolic compounds, synergistic interaction , hypoglycemic action , significant decreasing , anti – diabetic plants .