Cyclic Voltammetric Study of Paracetamol at Nickel Hexacyanoferrate Modified Carbon Paste Electrode

Abstract

Electrochemical response characteristics of modified carbon paste electrode towards detection of paracetamol was investigated by cyclic voltammetric technique in 0.1 M acetate buffer solution containing 0.1 M KCl as supporting electrolyte. In the present work, carbon paste (CPE) was prepared by grinding the mixture of dry graphite powder and paraffin oil of ratio 75:25 respectively. Nickel Hexacyanoferrate modified carbon paste electrode was developed by immobilizing different ratios of Nickel Hexacyanoferrate. The best ratio was 20% (w/w) NiHCF; 55% graphite and 25% (w/w) paraffin oil respectively. The peak currents in voltammogram of paracetamol were increased at Nickel Hexacyanoferrate modified carbon paste electrode when compared to unmodified carbon paste electrode in 0.1 M acetate buffer solution containing 0.1 M KCl of pH 7.5 at scan rate of 100 mV/s. The electrode process of paracetamol was examined and then some of the experimental parameters which affect the electrochemical response of paracetamol, such as pH, scan rate and ratio of modified carbon paste electrode have been studied. The effect of scan rate showed that the electrode process was both diffusion and surface controlled.

Keywords: Paracetamol, Nickel Hexacyanoferrate, cyclic voltammetry, Modified Carbon Paste Electrode