Synthesis and Characterization of Novel Schiff Bases, N-Acyl and Diazetines Derived from 3-((5-hydrazinyl-4-phenyl-4H-1,2,4-triazol-3-yl)methyl)-1H-indole

Kadhim M. Lazim AL-Aliawi, Jumbad H. Tomma, Khalid F. Ali


This work involves synthesis of some new heterocyclic compounds including 1,3-diazetine. The new Schiff bases[VI]a-d derived from 3-((5-hydrazinyl-4-phenyl-4H-1,2,4-triazol-3-yl)methyl)-1H-indole [V] which was synthesized by refluxing 5-((1H-indol-3-yl)methyl)-4-phenyl-4H-1,2,4-triazole-3-thiol[IV] with hydrazine hydrate in absolute ethanol and this amino compound[V] condensation with different aromatic aldehydes in absolute ethanol to yielded a new Schiff bases[VI]a-d. N-acyl compounds[VII]a-d were synthesized by addition reaction of acetyl chloride to imine group of Schiff bases in dry benzene. The new diazetine derivatives [VIII]a-d synthesized by the reaction of N-acyl compounds[VII]a-d with sodium azide in dimethylformamid at (55-60) 0C. All the synthesized compounds have been characterized by melting points , FTIR and 1HMNR spectroscopy (of some of theme).

Key words : Schiff bases, N-Acyl, Indole, Diazetine.

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ISSN (Paper)2224-7181 ISSN (Online)2225-062X

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