Effects of Pulmonary Tuberculosis Treatment for 2 Months, 4 Months and 6 Months on Total Protein, Albumin, Globulin, 1gG & 1gM in Pulmonary Tuberculosis Infected Participants

Abstract

This present study was designed to determine the effect of pulmonary tuberculosis treatment for 2 months, 4 months and 6 months on total protein, albumin, globulin, IgG and IgM in pulmonary tuberculosis infected participants in Anambra State, Nigeria. A total of 220 pulmonary tuberculosis infected subjects aged 18 – 60 were recruited for the study. After informed consent and ethical approval, blood samples were collected for analysis. Serum proteins were assayed using biuret method. IgG and IgM were assayed using turbidimetric method. Tuberculosis diagnosis was also carried out using Ziehl Neelsen technique. The result showed that the mean ±SD concentration of total protein (g/dl), globulin (g/dl), IgG (mg/dl) and IgM (mg/dl) were significantly higher in tuberculosis infected participants compared (in each case) with the control subjects, 2 months, 4 months and 6 months treatment subjects (P<0.05). The mean ±SD albumin concentration was significantly lower in tuberculosis infected participants compared in each case with the control subjects (P<0.05). The present study showed increase total protein, globulin, 1gG and 1gM in pulmonary tuberculosis infection. The serum concentration of these parameters returned to normal as patients undergo treatment. Therefore we recommend that total protein, albumin, globulin, 1gG and 1gM should be considered as one of the baseline test for tuberculosis infection.

Keywords: Pulmonary tuberculosis, total protein, albumin, globulin, 1gG, 1gM.