Detection Zinc and Copper Serum in HelicobacterPylori-Infected Patients

Abstract

Background and Objectives: Helicobacter pylori (Hp) colonizes the human gastric and duodenal mucosa and the infection maycause peptic ulcers and gastric adenocarcinoma..Most study appear thate (HP) infection effect of defferent micronutretion zinc and copper The purpose of the study wasto compare serum concentrations of

trace elements (zinc [Zn], copper [Cu] of HelicobacterPylori-Infected patients with those of healthy subjectsand to determine the relationshipsbetween trace elementsMaterials and Methods: The study was conducted in 45Helicobacter pylori (Hp) infection patients and 20 age- andgender-matched healthy volunteers.Flame atomic absorption spectroscopymethod was employed to analyze serum trace element concentrations zinc and copper.  Results: Compared to the control subjects,45Helicobacter pylori (Hp) infection patients had significantly(P < 0.05) Independent sample t-testdepicted that serum concentrations ofZn  were decreased while serum concentration of Cu increased significantly in the  Helicobacter pylori (Hp) patient group The concentrations of Zn, Cu, and were 92.8 mg/L and132.2?g /L, respectively,in Helicobacter pylori (Hp) infection patients, and 142.3 mg/L and84.2 mg/L respectively, in the healthy controls..Conclusion: Helicobacter pylori (Hp) infection assosated  with metabolism zinc and copper, Serum concentrations of Zn were decreased, but serum concentration of Cu increased significantlyin Gastritis Helicobacter pylori patient groups.

Keywords- Gastritis Helicobacter pylori  ,  serum zinc (Zn) , serum copper( Cu).