Calcium Channel Blocker (Quinidine) as a New Approach of Male Contraception: A Review

Abstract

The intentional avoidance of conception via the using a various strategy, sexual practices, chemicals, drugs or surgical method. A successful contraception was permitting a physical relationship between partners without worrying about an unwanted pregnancy and makes sure a freedom to have children when in demand. The purpose is to attain contraception with a highest confidentiality and a minimum cost and side effects. Even though, the intention to finding a new approach of male contraceptives through targeting ion channels was disturbed by lacking the most molecular basis of channels to effect on sperm function. Recently, there is developing of a new approach push of male contraception, based on targeting specific processes in sperm development, maturation, and function by using quinidine as a one of calcium channel blocker. Consequently depending on previous findings and researches on sperm-specific Ca²⁺ channels, as new non-hormonal drug targets for male contraception.

Keywords: Catsper, Male Fertilely, Contraception, Ca²⁺ Channel Blockers