Toxicological Pathology of Contraceptive in Rat by Oral Intubation for Six Months

Abstract

The study was done on laboratory white rats(Sprague dawelly) in 2groups, 8 male and female as untreated control and 8 male and female as treated with contraceptive pills. The study showed that untreated animals were normal in breeding respect while treated animals showed no evidence of breeding at all and histopathologically untreated controls showed normal ovaries and testis while treated animals showed atrophy of ovaries and marked suppression of spermatogenesis. Other histopathological changes were also seen in liver and kidney.

Keywords: contraceptive, ovary, testis and rat