Evaluation of Some Serum Biochemicals that Associated with Antioxidant Status in Periodontitis Patient in Relation with Gestational Diabetes

Abstract

Periodontal disease is inflammatory disease that characterized by oxidative stress and inversely associated with antioxidants. Gestational diabetes mellitus (GDM) occurs with variable severity in 3%-5% of all pregnancy may be associated with oxidative stress and impairment of antioxidant defense. In previous cross –sectional or case control studies,clinical periodontal disease has been associated with GDM .This study was carried out to assess the association between the periodontal disease and (GDM). 80 pregnant women were participated in this study, 40 of them were diagnosed with GDM. Full mouth periodontal examination with some serum biochemical that associated with antioxidant status: uric acid, bilirubin, and total protein parameters were performed for all participants. The results of the study showed a significant decrease in serum uric acid and bilirubin in periodontitis groupsas compared with non-periodontitis groups in both pregnant women with and without GD, while serum total protein decreasednon-significantly in periodontitis groups than in non-periodontitis. The results of this study support the hypothesis of the association of periodontal disease with GDM.

Keywords: Periodontitis, Gestational diabetes mellitus, serum antioxidants.