Some Herbal Medicinal Plants Activity against Candida spp which Resistance to Antifungal Drugs

Abstract

Some medicinal plant that used as antibacterial in Iraq has been experimented as antifungal, five of these plants include Zingiber officinale, Salvia officinalis, Origanum vulgare, Glycyrrihza glabra, Punica granutum were used against four species of candida spp. C. paracitucus ,C. albicans, C.tropicus ,C.kruzi, which are resistance to antifungal drugs, 80% methanol was used to extract these plants, 5 mg/ml of each extracts used in nutrient broth for 4 days to evaluated anti-candida activity. The Results show that plants extracts causes complete inhibition ,decreased in candida growth ,don’t effect on activated candida growth, Zingiber officinale causes complete inhibition to candida spp except C. albicans, Salvia officinalis was decreased in all candida spp, Origanum vulgare, effect on C. albicans and C, kruzi but it don’t effect on other species. Glycyrrihza glabra decreased all candida spp. Punica granutum decreased growth of C. albicans and C. kruzi only.

Keywords: Candida spp , plant extract, 80% methanol.