Comparative Biochemical and Metabolic Alteration in Newly Diagnosed Hypertensive and Normotensive Subjects

Abstract

This study was carried out to observe biochemical and metabolic alteration in newly diagnosed subjects with essential hypertension when compared with normotensive subjects in both men and women within the age ranges of 31-40, 41-50 and 51-60 years. The plasma electrolytes were measured photometrically while bicarbonate was measured using back titration method. Other plasma analytes were measured colorimetrically. The mean value of plasma sodium, creatinine, urea, total cholesterol, low density lipoprotein-cholesterol, triglyceride, and 2 hour post- prandial were found to be significantly increased (p<0.0001) while plasma potassium, high density lipoprotein-cholesterol mean values were found to be significantly lowered (p<0.0001) except calcium with clinically significance when compared with standard. Plasma mean values of fasting blood sugar, total protein and albumin showed no significant changes which may be due to non involvement of renal damage effect of hypertension especially for plasma proteins. This work shows that incidence of essential hypertension is accompanied by biochemical and metabolic alteration and this can serve as a line of investigation for proper diagnosis and treatment.

Keywords: Hypertension, Metabolic effect, Blood pressure, Sodium