Bioactive compounds from Acokanthera oblongifolia

O. M. M. Sabry, Abeer M. El Sayed, Shahira M. Ezzat, Zeinab Yousef


One cardiotonic glycoside, three triterpenes and one steroidal glycoside were isolated from Acokanthera oblongifolia fruits (pericarp) growing in Libya. Their structures were investigated by extensive application of IR, MS, 1DNMR and 2DNMR spectroscopy. The isolated compounds have evidenced in-vitro cytotoxicity on selected human cell lines (A-549, H-1299) when compared to doxorubicin.

Keywords: Cardenolide; Acokanthera oblongifolia; antitumor activity; lung carcinoma cell line (A-549, H-1299).

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ISSN (Paper)2224-7181 ISSN (Online)2225-062X

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