Use of Biochemical Markers in Predictive and Diagnostic Means in Diagnosing Obstetrical Pathologies in Albania

Genc Kabili, Rustem Celami, Diamantis Daphnis, Ela Petrela, Denisa Golemi, Lediana Thano



The majority of published scientific papers concerning the role of biochemical markers of first trimester such as PAPP-A and free-ß-hCG in predicting future pregnancy complications enhance the importance of these parameters.


To evaluate the role of biochemical markers parameters in other pregnancy disorders after first trimester such as Fetal Growth Restriction, Preeclampsia, Preterm Birth, Stillbirth, Fetal Macrosomia.

Materials and methods:

As a part of a prospective study, we did study 866 patients that were followed from the beginning of pregnancy to delivery, after giving their agreement. Quantity and quality research methods were used and data was analyzed by IBM SPSS Statistics.


Our data of showed that 11.4% of this cohort presented one of the above respective pathologies. The risk was better related to MoM PAPP-A than free-ß-hCG. Patients with MoM PAPP-A less than cut off 0.5, has double risk of having the pathology comparing to those patients with


Consequently, the value of counseling the patient so early, with the information taken from evidence based medicine, has importance for them, in order to be more careful after having the results, and make regular control with their physician.

Keywords: Biochemical markers, pregnancy complications, Down syndrome.

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ISSN (Paper)2224-7181 ISSN (Online)2225-062X

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