Study the correlation between hormonal receptors in Iraqi patient women with Breast Cancer

Abstract

Breast Cancer is one of common types of cancer in the world and is considered one of the causes of death among Iraqi women . The discovery of the hormone receptors (estrogen and progesterone) a significant impact in the selection of patients for treatment and expected to live after period and to the possibility of recurrence treatment again is because the relationship between tumor grade and the percentage of representation of hormone receptors on the surface cells . The research based on measuring the proportion of ER and PR in tissue and blood serum and note relationship between the level of receptors and the clinical situation in Iraqi women with breast cancer . The study has been started from May 2014 to December 2014 in the Educational Tumor Hospital were selected infected women in the age group (28-68) years as measured by the proportion of their ER and PR in tissue and serum .The results showed that the proportion of women  with a family history of patients is 62.5% and that the patients whose ratio to have a tumor of the second degree is 76.7% and the third degree was 13.3% and that the first degree ratio is 10% and that there is no significant difference in the measurement of the percentage ER and PR in ELISA technique and Immunohistochemistry . Sensitivity and Specifity of Immunohistochemistry study is better than ELISA technique because the value of IHC sensitivity and specifity for  ER and PR are 70%(1.0)ng/ml and 69%(1.0)ng/ml respectively while in ELISA technique are 38%(0.9)ng/ml and 20%(0.95)ng/ml respectively .

Keywords: Breast Cancer, Estrogen receptors , Progesterone receptors .