Serum Glucose Level of Alloxan Induced Diabetic Rats Treated With Glutathione Complex

Abstract

Antioxidant plays an important role in preventing the progression of diabetes mellitus (DM) complications. This study was undertaken to evaluate the hypoglycemic effect of glutathione complex in Alloxan induced diabetic rats. Thirty albino rats (weighing 120-130g) were divided into six groups of five rats each: Group one serves as normal control, group two served as diabetic control while Group three, four and five were diabetic and administered with 2.4mg/kg body weight, 3.6mg/kg body weight and 4.8mg/kg body weight respectively. All treatments were administered orally for 4 weeks on daily basis. Serum glucose level was measured at an interval of three days throughout the period of the experiment. Results obtained showed that administration of Glutathione Complex to diabetic rats caused a significant decrease (p<0.05) in serum glucose level compared to diabetic control. These results suggest that administration of Glutathione Complex to diabetic rats may help reverse the complications of diabetes mellitus.

Keywords: Alloxan, Diabetes, Glucose and Glutathione Complex

DOI: 10.7176/ALST/84-03

Publication date: December 31^st 2020