Expression of Pro Inflammatory Cytokines and Anti-Chlamydia Antibody in Bacterial Ocular Infection.

Abstract

Current study was done to investigate the bacterial causes of eye infection for 130 patients with different ages in Babylon city , the study includes swab for eye and sample of blood. Bacteriological diagnostic  for eye swab which taken from different site include Conjunctivitis, Dacryocystitis, Lidinfection showed variation in types and number of isolates . Gram positive bacterial isolates include Staphylococcus aureus 67 (38.06%), Which represent the predominating bacteria, Staphylococcus epidermidis 18 (10.22%), While gram negative bacteria represent Escherichia coli 40 (22.7%), Neisseriae gonorrhoeae 5 (2.84%).

Detection of Chlamydia trachomatis reveals only one positive case  out of 42 eye infected case for anti Chlamydia IgG –IgM ( 3.7 %),

Immunological test of Cytokine IL-6 in patient show increased in their concentration compared with healthy at P< 0.05 reached 8.52 pg/ml especially at age group 41-50.

IFN-? also show increased in their concentration in patient than controls although, there is no significant differences between patient and control groups. .

Key words ; IFN gamma , IL-6 , eye infection , bacterial isolates ,Chlamydia trachomatis