Studies on the Chronic Consumption of Thermo Oxidized Palm Oil on the Histomorphology of the Cerebellum in Mice

Abstract

The effect of thermoxidized palm oil (TPO) diet on the histomorphology of cerebrum was studied using mice.  Thirty (30) albino mice weighing between 18-24g and aged 2-4 weeks were grouped into two groups; fifteen (15) animals each group and fed, TPO diet and normal rat chow (control diet) for 14 weeks. Body weight change was significantly lower in the TPO group compared to control (p< 0.01). Histologic micrograph showed hyperchromasia of the granule cell layer of the cerebellum in TPO. From the results, thermoxidised palm oil diet may have adverse effects and degenerative changes in the cerebellum.

Keywords: Chronic consumption, Thermo-oxidized palm oil, Cerebellum, Histomorphology.