Production of Nanocurcumin from Curcuma Xanthorriza Roxb. by Homogenization

Abstract

Curcuma xanthorriza Roxb. contain yellow pigments known as curcuminoids (curcumin, bidesmetoxicurcumin and monodesmetoxicurcumin), protein, phosphorus, potassium, iron and vitamin C, with curcumin as the highest component (50-60%). Curcuma xanthorriza Roxb. has been used widely for treatment of lack of appetite, stomach ulcers, eczema, and acne. Its mainly the effect of curcumin compound. Curcumin has a low bioavailability and poor-water solubility, to enhance it properties, the curcumin convert to nanocurcumin. Nanocurcumins stabilized by Tween 80 were prepared by homogenization. The research was able to produce nanocurcumin with the droplet size less than 100 nm from Curcumin solution, by using a variation of the stirring speed (8,944, 10,822 and 12,879 g), time (20-40 min) and curcumin concentratiom (20 and 30%). The droplet size that lower than 100 nm were using 30% curcumin concentration, stirring speed of 12,879 g  for 40 minutes. The nanocurcumin showed increased solubility and bioavailability compared to the extract emulsion.

Keywords: Curcuma xanthorriza Roxb., homogenization, nanocurcumin