Postprandial hypertriglyceridemia and androgen dysfunction relationship in men with end stage renal disease

Abstract

Background: Gonadal function is affected with end stage renal disease. In men the   disturbances of the hypothalamic–pituitary–testicular axis can be detected with only moderate reductions in the glomerular filtration rate.  There are many evidences that confirm the effect of testosterone on lipid metabolism in postprandial state.

Objective: to study the relationship between low level of total testosterone and postprandial lipids in male patients with end stage renal disease.

Subjects &Method: the study involved 38 male patients with end stage renal disease ( age range of 30- 60 years ) attending the unit of kidney disease and transplantation at Baghdad Teaching Hospital , and 35 healthy subjects (control group ) of matching age and weight during the period from January  to march 2013. Postprandial venous blood was obtained for glucose, lipid profile, urea and creatinine measurement   immediately after separation of the serum by routine colorimetric methods  .

The determination of androgen sex hormones (luteinizing hormone , follicle stimulating hormone , testosterone , and  sex hormone binding globulin ,) was done using Enzyme-Linked Immuno Sorbent Assay. (Sandwich assay).

Results: There was a significant negative correlation between free testosterone, and postprandial triglyceride in both ESRD patients and control groups with a significant difference in testosterone between these two groups.  The sex hormone binding globulin was also correlated negatively with postprandial triglyceride in the control group.

Conclusion: Decline in free testosterone level associated increased postprandial hypertriglyceridemia, which could, both, be considered predictors for cardiovascular disease risk factors in male patients with ESRD.

Key words : Postprandial hypertriglyceridemia , free testosterone, androgen dysfunction ,ESRD.