Comparative effect haloperidol and quetiapine within positive symptoms for female schizophrenic patient

Abstract

Schizophrenia is a worldwide public health problem that requires a lot of personal and economic costs. Schizophrenia affects approximately 1% of the world's population. Anti-psychotic drug used in the treatment of schizophrenia have varying pharmacologic properties, first-generation antipsychotic Drugs such as neuroleptics is due to neurologic side effects equation. The second generation of antipsychotics or newer fewer neurological effects. In-depth research related to the use of antipsychotics, especially on the improvement of positive symptoms in schizophrenic patients are still very few women. methods; This research is an experimental study, the two forms of group pretest posttest design, which uses a questionnaire Positive and Negative Syndrome Scale (PANSS) is a valid measurement tool to assess the severity of symptoms experienced by patients with schizophrenia and an assessment of the output terapeutik. Kriteria Inclusion: Female Patients , age 15- 55 years, Body Mass Index from 18.50 to 24.99, have the same severity, acute phase, Exclusive criteria; hypersensitivity to quetiapine or haloperidol,komorbiditas pregnant and general medical illness, organic mental disorder or disturbance other psychiatric systolic blood pressure <100 mmHg. Of the study obtained for the largest proportion of the study subjects quetiapine group was aged 15-24 years, while for the 45-55 age group. haloperidol significantly different on demographic factors; age, occupation, marital status, and the educational status.Has the significant differences in scores on the PANSS positive scale and the third week, fourth drug intervention using either quetiapine or haloperidol (P<0.05). The proportion of the largest studies on the subject of female schizophrenic patients grouped quetiapine is aged 15-24 years and 45-55 years, while haloperidol obtained difference scores on the PANSS scale significantly positive drug intervention on the day the third and fourth.

Keywords: female schizophrenic patient, PANSS, quetiapine, haloperidol