A Histopathological Study And Antioxidant Effect Of Ginger To Diminishing Poisoning Lead Acetate-Induced Hepatopathy In Rabbits For Three Months.

Abstract

Lead acetate is an example of heavy metals that for decades being known for its adverse effects on various body organs and systems such that their functions are compromised. The present study, carried out to evaluate histopathological changes in rabbits liver induced by lead acetate toxicity and to investigate the therapeutic effects of ginger against lead poisoning. Ginger is source of antioxidants was administered orally to prevent the adverse effects of lead acetate. Thirty rabbits, randomized into 3 groups (n = 10), were used for this study. Animals in group (A) served as the control and were drinking distilled water. Animals in groups (B) and (C) were drinking 2% lead acetate. Group (C) animals were, in addition to drinking lead acetate, treated with 100 mg/kg/rabbit of ginger. All treatments were for 3 months. The obtained results showed that lead acetate caused histopathological changes were seen in the liver such as (vacuolation, degeneration, fibrosis and inflammation) and a significant reduction in plasma superoxide dismutase and catalase activity, but a significant increase in plasma malondialdehyde concentration, using ginger cause to modified these harmful effects. These findings lead to the conclusion that ginger significantly decreased the adverse harmful effects of lead acetate exposure on the liver as well as ginger may exert its protective actions against lead induced histopathological changes in liver tissue.

Keywords: Ginger, Lead acetate and hepatopathy.