Changes in Aortic Vasa Vasorum Associated with Rabbits Hyperimmunization with Pseudomonas Aeruginosa

Shurooq Ibrahim Mahmood


Aortic adventitial vasa vasorum (vv) is an essential network of microvesseles that participates in providing nutrient , oxygen , besides being a source of stem cell for neovascularization (vv) is involved in inflammatory response in atherosclerosis . Male rabbits were immunized with heat killed , Whole bacteria, rested for two weeks and aortic base region were processed for histological examination . In addition  the sex-steriods hormonal levle were estimated by ELISA . The results demonstrated that immunized rabbit showed prominent thickened tunica media with signs of smooth muscle cell proliferation . The most interesting findings included increased angiogenesis . Rabbits showing these changes demonstrated increased testosterone 5.77± 3.78 in test versus 1.25 ±  0.87 in control (P=0.089) . progesterone and estradiol didn’t show any changes in test animals . These results implicate that contineous exposure to bacterial constituents  could  induce atherosclerotic lesion in aorta vasa vasorum.

Keywords:Vasa Vasorum (VV) , Immunization, Pseudomonas aeruginosa


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ISSN (Paper)2224-3208 ISSN (Online)2225-093X

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