Thrombophilia: Factor V Leiden Mutation as a Genetic Background in Patients with Retinal Vein Occlusion

Abstract

Aim: This study was designed to detect the association between factor V Leiden mutation and retinal vein occlusion.Methods: A total 60 adult newly diagnosed retinal vein occlusion patients ( branch or central types) with or without systemic disorders were included in this study in addition to 84apparently healthy adult control persons. Factor V Leiden mutation by PCR- RFLP technique was done for all cases of patients and controls groups.Results: The number of patients express FVL mutation was 13/60 (21%), while that of control subjects 7/84 (8.3%)and the P- value reach to (0.023).The Odd ratio was 3.043 with a confidence interval of (1.133-8.171)that indicate a strong association between FVL mutation and retinal vein occlusion. At the same time the etiologic fraction (EF) was 0.436which mean that FVL mutation remain as a risk factor not a cause for retinal vein occlusion.Conclusions: FVL mutation is significantly higher in patients than control group, and consider a strong risk factor for retinal vein occlusion.

Keywords: Factor V Leiden, Thrombophilia, Retinal vein occlusion.