Evaluation of some Marker Enzymes, Prostaglandins, C-Reactive Protein and Plasma Total Protein, in Pregnancy Induced Hypertension among women in Ekiti State, Nigeria

Abstract

This study was carried out to evaluate the levels of some marker enzymes, Prostaglandins,  C-Reactive protein and Total protein in women with pregnancy induced hypertension (PIH) and  normotensive pregnant  women  in Ekiti state, Nigeria. The patients were got and nurtured at the university teaching hospital and Federal medical Centre located in different towns within the state. The results obtained revealed no significant change (p<0.05) in the activities of the enzymes; Acid Phosphatase(ACP), Aspartate Aminotransferase (AST), Alanine aminotransferase (ALT), Lactate Dehydrogenase (LDH) in both normotensive and hypertensive pregnancy. However, Alkaline phosphatase showed a significant decrease (p<0.05) in patients with PIH. Prostaglandins assayed for revealed a significant increase (p<0.05) in both normotensive and hypertensive pregnant patients, but patients with PIH showed a higher significance. It was also observed that C-reactive protein significantly increased (p<0.01) in pregnant women with PIH. The results further revealed a significant decrease (p<0.05) in the level of  Total  Protein in women with PIH only. This study reveals that  PIH is associated with reduced levels of Total Plasma Protein and raised levels of C-Reactive Protein and Prostaglandins. Also, it can be said from the result that PIH does not bring about significant changes in the activities of the marker enzymes examined apart from alkaline phosphatase which was implicated.

Keywords: Marker Enzymes, Prostaglandins, C-Reactive Protein, Total Protein, Pregnancy Induced Hypertension(PIH), Acid phosphatase(ACP), Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT),Aspartate Aminotransferase (AST), Lactate dehydrogenase(LDH).