Correlation between pregnyl response and blood groups in infertile men

Abstract

Pharmacogenetics is one of the factors that effect on drug  response and for the important of this subject, the study researched the correlation between the blood group and therapeutic response in infertile patients who are treated by pregnyl.

Forty  patients of different blood groups subdivide to four groups each one composed of ten patients of the same blood type as follow ten patients of blood group A, ten of B, ten of AB and ten of blood group O. From each patient collected two seminal samples one before treatment and the other after three months of treatment and analyze the seminal fluid to detect sperm concentration.

Result: the paper show the patients of blood group O are more response (increase sperm concentration) compare with other blood groups while those of group AB not significantly response, patients with blood group A are significantly response ( p<0.05) (increase sperm concentration) and those with blood group B are also significant (p<0.05)  but by lesser degree than group A. There is relationship between blood group and treatment response.

Keywords: Spermatogenesis, Male infertility, Pregnyl, Blood group, Pharmacogenetics.