The correlation Between Vitamin D Metabolite Levels With Relapse Rate And Disability In Multiple Sclerosis

Abstract

Background: Multiple sclerosis is a major cause of disability in young adults. Vitamin D is a potent immunomodulator and the protective effect of Vitamin D on multiple sclerosis is supported by the reduced risk associated with sun exposure and use of Vitamin D supplements. Moreover, high circulating levels of Vitamin D have been associated with lower risk of multiple sclerosis. Objectives: The aim of this study is to clarify the relationship between vitamin D metabolite level and disability and relapse rate in multiple sclerosis. Methods: Fifty four Multiple sclerosis patients fulfilling McDonald's criteria and 70 controls matched in age, sex and same geographical areas,35 (64.8 %) patients were with relapsing remitting type,9 (16.6 %) patients were primary progressive type and 10 (18.6 %) patients were secondary progressive type. For the control group, 28 of them were with non-MS demyelinated neurological diseases including 18 with chronic inflammatory demyelinating polyneuropathy, 6 were Gillian Barrie syndrome and 4 were acute demyelinating encephalomyelitis, and the remaining forty two were apparently healthy controls. All multiple sclerosis patients and controls are subjected to assessment of 25(OH) D serum level by RIA. Results: very high statistically significant difference between patients and controls, also very high statistically significant negative correlation in all patients, and disability and relapse rate                                               .                                                                                                                Conclusion: There is an important role of vitamin D in outcome of multiple sclerosis and the relapsing rate of the relapsing remitting type

Keywords: multiple sclerosis,vitamin D,relapse,disability