Resistance Pattern of Levofloxacin against Uropathogens Causing Urinary Tract Infection in Selected Areas of Dhaka city, Bangladesh

Abstract

A crucial public health problem in developing country like Bangladesh is resistance of antibiotics to different types of bacteria and the rates of these bacterial resistances are changing for various antibiotic therapy. Our aim was to assess the susceptible pattern of Levofloxacin a 3^rd generation Quinolone antibiotic against uropathogens. A total of 12943 urine samples were collected in 2016 (Jan-Dec) and out of which 1236 (9.55%) were bacteriologically positive. Among the isolated uropathogens, 95.1% were gram negative and 4.9% gram positive organism. Male were found more prone to get UTI under 10 years and between 51-90 years of age and female were more affected in 10 to 50 years and over 90 years of age group. E. coli was the most prevalent (83.9%) isolate followed by Klebsiella spp. (6.7%), Staphylococcus aureus (2.6%), Pseudomonas spp. (2.2%), Enterococcus spp. (2.0%) and Proteus spp. (1.1%). The most predominant Levofloxacin sensitive organisms were found in male Enterobacter spp. (100%) and in female patients Serretia spp. (100%), Citrobacter spp. (100%) and Streptococcus Group B (100%). On the other hand the most predominant Levofloxacin resistant organisms were found in male and female both Acinetobacter spp. (100%). Around (61.7%) male and (46.9%) female were found resistant to E. coli.

Keywords: Levofloxacin, Quinolone, UTI, Resistance, Uropathogen.