Effect Of Glucosamine On The Healthy Status Of Diabetic Rats

Abstract

This search focuses on glucosamine as a drug using in the treatment of diabetes, especially in Egypt. Diabetes is an important human ailment afflicting many from various walks of life in different countries. In Egypt it is proving to be a major health problem, especially in the urban areas. Though there are various approaches to reduce the ill effects of diabetes and its secondary complications. One of the etiologic factors implicated in the development of diabetes and its complications is the damage induced by free radicals and hence an antidiabetic compound with antioxidant properties would be more beneficial. Therefore information on antioxidant effects of these medicinal drugs is also included and investigated. Diabetes is a chronic metabolic disorder characterized by altered carbohydrate, fat and protein metabolism, and an increased risk of multiple complications. Effect of glucosamine at doses of 1,1.5 and 2 g ?kg b.w on alloxan-induced diabetic rats were studied, Sprauge-Dawley albino rats (30 male) , weighing 150 ±5 g were divided into 5 groups and administered glucosamine daily for 28 days. Blood samples were taken from each rat and tested for blood glucose, total cholesterol, (LDL), (HDL), triglycerides, urea, uric acid, creatinine levels and liver enzymes activities. Blood glucose, triglycerides, total cholesterol, LDL, urea, uric acid, creatinine and liver enzymes activities (AST and ALT) were significantly increased, while HDL, was significantly decreased compared with the negative control rats. Treating diabetic rats with 1,1.5 and 2 g ?kg b.w caused a significant improvement in these biochemical measures and the best results were achieved by using 2 g ?kg b.w followed by1.5 and 1 g ?kg b.w, respectively.

Keywords: glucosamine, treatment of diabetes, diabetes complications, total cholesterol.