Review on Approaches of A Reverse Vaccinology for Dangerous Pathogens of Animal

Henok Mulatu


The traditional method of vaccine development includes pathogen culture in the laboratory, but this is not possible in the case of highly infectious pathogens that are hazardous to culture in the laboratory.Reverse vaccinology is regarded as a low-cost and effective method for screening the entire pathogen genome. The incorporation of the pangenome concept into the reverse vaccinology approach is critical in the search for broad-spectrum immunogenic targets and the analysis of closely related bacterial species.. The heart of reverse vaccinology is the selection of specific epitopes of interest capable of eliciting both cellular and humoral immune responses. Reverse vaccinology has also been used to combat viruses. The processes behind the development of protective immunity, and the principles that will direct the creation of the next generation of vaccines by using genomic techniques to investigate both the pathogen and the host. This review demonstrates the advancement of reverse vaccination, their applicability, and their limitations in the timely creation of effective vaccines against the most deadly infections.

Keywords: Vaccines, Epitope Prediction, Immunizations,Reverse Vaccinology

DOI: 10.7176/JBAH/13-15-03

Publication date:September 30th 2023

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ISSN (Paper)2224-3208 ISSN (Online)2225-093X

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