Measuring the Impact of Schistosomiasis Infection on Different Blood Parameters

Abstract

Background.

Schistosoma is a genus of trematodes, Schistosoma spp., commonly known as blood-flukes and bilharzia, cause the most significant infection of humans by flatworms and are considered by the World Health Organization (WHO) as second in importance only to malaria.

Objective of the study .This study was carried out in Sudan in the period from December 2009 to  February 2010 to assess effects Schistosomamansoni on hemoglobin (Hb) level, red blood cell count (RBCs count), total leucocyte count (TLC), paced cell volume (PCV), mean cell volume (MCV), mean cell hemoglobin (MCH), mean cell hemoglobin concentration (MCHC), and total platelet count .

Study design .One hundred Schistosomamansoni infected patients included in this study ( 77 males , and 23 females).More fifty  samples were collected from normal persons and used as control. Density of parasitemia was calculated using Kato Katz technique. 5 ml venous anticoagulated blood were drawn from each participant . blood was analysed for aboved parameters using Mythic 18 cell counter.

Results. the results showed that the means of different blood parameters were as followed : Hb:13 g/dl, PCV:40%, MCV:78 fl, RBC:5.2X 10¹²/L, MCH: 25pg, MCHC: 31g/dl, TLC: 7.4x10⁹/L, and Total Platelet count:245x10⁹/L in male group, and Hb: 12g/dl, PCV: 37%, MCV: 74 fl, TRBC: 5x10¹²/L, MCH: 23 fl, MCHC: 31g/dl, TLC: 6.7x10⁹, and total platelet count: 240x10⁹/L for female group.

Conclusion. The study concluded that there a reduction in most parameters when compared to control group. Also this study reported a significant reverse association between density of parasitemia in all parameters except TLC and TRBC.

Key words. Schistosoma mansoni, blood parameters, Halfa Aljadeeda town, Sudan