Hepatotoxic of Glugophage

Abstract

Study aim to detection side effects of Glucophage in liver tissue in white albino mice, three doses used in present study, 50, 100, 150 mg\kg for 4 weeks, results of histology studying show that dose 150 mg\kg causes changes in liver of mice, infiltration and congestion, presence of edema fluid and changes in cytoplasm of hepatocyte was occur in liver of mice.

Study concluded that drug must be used in low dose in non-diabeticpation.

Keywords: Glucophage, infiltration, congestion