Biochemical Changes in Relation to Blood Hemoglobin of Anemic Heamodialysis Patients Treated with Mircera at AL- Hussein Dialysis Center in Thi-Qar Province / Iraq

Abstract

Background : Anemia is a reduction in the number of RBC count and resulting mainly from reduced erythropoietin production due to the damage or loss of kidneys function in chronic renal failure ( Renal anemia) and is a common complications in hemodialysis patients.

The objectives: This study design to evaluate the changes in some biochemical parameters and the relation with blood hemoglobin, for post-heamodialysis patients treated with stable dosage of Mircera ( Methoxy polyethylene glycol - epoetin beta 75 µg/0.3 ml, Germany).

Patients and method: Blood of 95 patients were collected from AL- hussien dialysis center in Thi-Qar province / Iraq within three months period, number of dialysis session was two time per week for two hours each session. After heamodialysis session, patients treated with stable dosage of Mircera (0.6 µg) for every kilogram of body weight once every 2 weeks . The data and biochemical finding of their blood sample collected after heamodialysis session.

Results: A ninety fife HD patients included 65 (68.4%) were male and 30 (31.6%) were female, aged between 19 to 65 years, their total body weight was 59.34 ± 1.33 Kg and their blood analysis are normal glycemia 5.4 ± 0.51 mmol/l , normal natraemia 137± 0.77 mmol/l, but hyperkalamia (6.1 ± 0.9 mmol/l) , hyperuraemia (21.78± 4.13 mg/dl) , hypercreatinaemia (2.2 ± 0.98 mg/dl) , and the mean HB value was (8.38 ± 1.18 g/dl). The results of response to Mircera show only one patient (1.05 %) had mean HB values (12.0 g/dL) within the target range recommended by KDOQI guideline. Seventy patients (73.69 %) had mean HB value between 8.0 to 10.9 g/dL, twenty four patients (25.26 %) had mean HB values between 5 - 7.9 g/dL and there are no one (0.0 %) had exceed the recommended range (>12 g/dL). Anemia degree positively related with hyperuraemia and hypercreatinaemia .

Conclusions: There are Hyporesponsiveness to mircera (75µg/0.3 ml) therapy in hemodialysis patients associated with reducing dialysis efficiency slightly for potassium, urea and creatinine and that positively related with anemia degree .

Keywords: Anemia , Mircera , Blood Urea, Blood Creatinine and Heamodialysis patients.