Role of Atorvastatin in Prevention of Intracranial artery Stenosis

Abstract

Objective: To find out the role of atorvastatin in prevention of intracranial artery stenosisStudy Design: Observational studyPlace and Duration of Study: We conducted this study in department of Medicine Nishter Hospital Multan and Ganga Ram Hospital Lahore from June 2017 to June 2018. Methodology: Forty two patients were selected for this study and every patient received clopidogrel and aspirin to prevent further cerebral infarction or transient ischemic attack. Group A and group B were formed. There are twenty one patients in Group A and they received atorvastatin 10mg per day. Twenty one patients of group B received atorvastatin 40 mg per day. VCT scanner was used to check out the effects of atorvastatin on the perfusion. . Descriptive data was compared by applying Independent T test and Chi-square test was applied on nominal data. Data was analyzed using SPSS v.23 and value of p ≤0.05 was considered statistically significant. Results: At 1 month visit, he incidence of TIA and cerebral infarction was 9.5% and 9.5% in group A and 4.7% and 4.7% in group B, respectively (p=0.678). At 12 month visit, he incidence of TIA and cerebral infarction was 23.8% and 19% in Group-A and 4.7% and 4.7% in group-B, respectively (p=0.049).  The difference was statistically significant.Conclusion: In our study we came to the conclusion that the use of atorvastatin is associated with decrease in risk of TIAs and stroke in patients of intracranial artery stenosis.

Keywords: Atorvastatin, Intracranial artery stenosis, statins, prevention.