Diagnostic Efficacy of Calretinin Expression in Various Histological Types of Ameloblastoma

Abstract

Objective: This study was conducted to evaluate the usefulness of calretinin as a confirmatory Marker for ameloblastic tissue.

Study Design: Prospective study

Place and duration: study was conducted in the Dental Section Allied Hospital, Faislabad and Sharif Medical and Dental College  from October 2017 to October 2018.

Methodology: A total of 50 patients was included in the study, main variables assessed in this study were positive predictive value neative predictive value, sensitivity, specificity and accuracy of calretinin in diagnosis of ameloblastoma. SPSS version 23 was used to analyzed the data. P value less than or equal to 0.05 was taken as significant. Study was started after permission from hospital ethical committee and patients were informed in detail about disease and procedure to be done. Non probability consecutive sampling was used.

Results: Estimated sensitivity was 78.9%, it means that of the patients with ameloblastoma on calretinin, 78.9% were diagnosed correctly. The estimated specificity was 16%. Positive predictive value was 60% and negative predictive value was 16%. The overall accuracy was 38% for diagnosing calretinin.

Conclusion: Ameloblastoma found to be an important immunohistochemical marker for ameloblastoma of ameloblastic epithelium and strong diagnostic tool for differential diagnosis of ameloblastoma.

Keywords: Ameloblastoma, Calretinin, Histopathology, immunohistochemical marker, Maxillofacial.