EFFICACY OF ORAL ZINC SULPHATE VERSUS TOPICAL APPLICATION OF SALICYLIC ACID (16.7%) & LACTIC ACID (16.7%) COMBINATION IN THE TREATMENT OF PLANTAR WARTS

Abstract

Background; Warts are common epidermal growths caused by human papillomavirus that often cause significant discomfort and embarrassment. Current treatment options include topical therapies, cryotherapy, laser vaporization, and surgical excision. Objective: To compare the efficacy of oral zinc sulphate versus topical application of salicylic acid (16.7%) & lactic acid (16.7%) combination in the treatment of plantar warts. Material and Methods; Group A, having 78 patients, was given oral zinc sulphate (10 mg/kg/day) in 2 or 3 divided doses. In group B, 78 patients were advised to apply a combination of salicylic (16.7%) & lactic acid (16.7%) once at night daily. In group A, using oral zinc sulphate, the treatment was given for two months and follow up continued for next 1 month. In group B, the topical preparation was also continued for 2 months or till the complete removal of warts. Results; Of these 156 study cases, 94 (60.3 %) were male patients while 62 (39.7 %) were female patients. Mean age of our study cases was 34.42 ± 9.87 years. Monthly family income up to Rs. 30000 was noted in 68 (43.6%) while 88 (56.4%) had monthly family income more than Rs. 30000. Mean weight of our study cases was 61.96 ± 10.29 kilograms. Mean height of our study cases 161.24 ± 12.23 centimeters. Mean BMI of our study cases was 26.52± 1.87 kg/m² and obesity was present in 31 (19.9%) of our study cases. Mean no. of lesions was noted to be 5.30 ± 2.45 lesions (with minimum no. of lesions was 4 and maximum no. of lesions was 10) and 131 (84%) had up to 5 lesions. Mean duration of disease was 4.69 ± 1.61 months and 112 (71.8 %) had disease duration up to 6 months. Efficacy was noted in 110 (70.5 %). Efficacy in group A was noted to be 83.3 % and in group B was 57.7 % (p= 0.001). Conclusion; Our study results support the use of oral Zinc Sulphate in the treatment of plantar warts as compared to the salicylic acid (16.7%) and lactic acid (16.7%) combination. Efficacy of Zinc Sulphate was significantly higher when compared with combination therapy and it was found to be safe and reliable mode of treatment having no side effects were observed in our study. Use of Zinc Sulphate can help to reduce chance of recurrence and disease morbidity. Being cost effective, it provides cheaper mode of treatment as compared with cryotherapy which is quite expensive which will provide economic relief to our large poor population. Early treatment can help patients to maintain routine daily lives and physical activities such as sports without any pain and side effects.

Keywords; Plantar warts, Zinc Sulphate, Salicylic acid, lactic acid.