ROLE OF LYCOPENE IN THE MANAGEMENT OF ORAL SUBMUCOUS FIBROSIS.

Abstract

Objective: In this study we investigate the effectiveness of lycopene in the management of oral submucous fibrosis (OSF) when intralesional steroids also given in combination. Methodology: This cross sectional study was done in Dental Section Allied Hospital, Faisalabad, Fatima Jinnah Hospital, Multan and Nishtar Institute of Dentistry, Multan  in duration of six months from September 2017 to April 2018. This cross sectional study was initiated after approval from hospital ethical board. Collected Information was entered in SPSS computer software version 23.1 and analyzed for possible results. Mean and SD was calculated and presented for quantitative data like age, VAS score and mouth opening. Frequency (percentages) were calculated and presented for qualitative data such as gender. Post stratification statistical chi square test was used to see effect modification. P value ≤ 0.05 was considered as significant. Results: Overall, there were 100% (n=354) patients. Total patients who were selected for the study had the habit of chewing areca nut either in natural form or in the form of Pan Masala, gutkha or mawa. Gutkha is the most common form of areca nut used, i.e. 65.8% (n=233) patients were using it. In pour study average increase in mouth opening from baseline (before treatment) was 2.34±1.03 mm in group A. 4.20±1.26 mm in group B and 3.40±0.19 mm in group C at six week. Conclusion: When Lycopene used combined with intralesional steroids and Hyaluronidase its effectiveness is better in improving the mouth opening its symptoms in patients with Oral Submucous Fibrosis (OSF). It was also found that there was no side effects.

Keywords: Lycopene, OSF, Mouth opening, burning sensation.

DOI: 10.7176/JMPB/52-15