To compare the effect of cyclizine, prochlorperazine and ondansetron in inhibiting postoperative nausea and vomiting following laparoscopic cholecystectomy

Abstract

Objective: To determine the efficacy of prochlorperazine, cyclizine and ondansetron in patients following laparoscopic cholecystectomy, in terms of prevention of vomiting and nausea. Study Type: Randomized Control Trial. Duration and Location of Study: Anaesthesia department of the Bahawal Victoria Hospital, Bahawalpur over a period of January, 2018 to January, 2019. Methodology: Total of 324 patients divided into Group P, group O and group C received prochlorperazine (10mg), ondansetron (4mg) and cyclizine (50mg) respectively. Every patient was asked to tell when he/she is feeling nauseous, vomited and used additional antiemetic drugs. Descriptive data was compared by applying ANOVA test and Chi-square or Fischer’s exact test was applied on nominal data. Computer software SPSS version 23 was used to statistically analyze the data. P ≤0.05 was taken as significant., Results: Although occurrence of side effects was slightly higher in group-P, but all the groups were not statistically diffrent (p-value 0.581, 0.500 and 0.544 for headache, dizziness and sedation, respectively). Nausea and vomiting was observed in 4.6% in group-O patients, 5.5% in group-C patients and 8.3% in group-P patients, difference being statistically insignificant (p=0.500)., Conclusion: From the results of this study it can be concluded that all the three drugs i.e. cyclizine, ondansetron and prochlorperazine are equally effective and there is no statistically significant difference in terms of prevention of vomiting and nausea in patients undergoing cholecystectomy through laparoscope.

Keywords: Ondansetron, Cyclizine, Prochlorperazine, postoperative nausea and vomiting

DOI: 10.7176/JMPB/52-16