Haematological Changes in Patients with Lymphoid Malignancies on Chemotherapy in Benin City, Edo State, Nigeria

Abstract

Chemotherapy continues to serve as the best option therapy in treating human malignancies that have undergone metastasis and cannot be managed solely by surgical removal or radiation. The aim of this study is to evaluate the clinical important of haematological parameters in the management of lymphoid malignancy patients on chemotherapy to ascertain the impact of such chemotherapy on them.. This study was carried out in one secondary and one tertiary health institution in Edo State. It was divided into three groups: lymphoid malignancy on chemotherapy, novel lymphoid malignancy and apparently healthy individuals as controls. Using aseptic precaution, 5ml of blood is collected into K₂EDTA container for full blood count analysis using KX-21NSysmex automated Haematology analyser 2004 model and data were analysed using student t test. The comparison between novel lymphoid malignant patient and controls indicate WBC, lymphocytes and platelet count increase significantly (P <0.05) while RBC, HGB, HCT decrease significantly (P <0.05) when compared with control. However, MCV, MCH, MCHC, monocytes and granulocytes were not significant (P>0.05). The comparison  between lymphoid malignant patient on chemotherapy and controls shows RBC, HGB, HCT decrease significantly when compared with control (P <0.05) while WBC, lymphocytes, platelet, MCV, MCH, MCHC, monocytes and granulocytes were not significant (P>0.05).When lymphoid malignant patient on chemotherapy and novel lymphoid malignant patient are compared, it shows RBC, HGB, HCT increase significantly when compared with novel lymphoid malignant patients (P <0.05) while WBC and MCHC decrease significantly (P <0.05). However, lymphocytes, platelet, MCV, MCH, monocytes and granulocytes were not significant (P>0.05). we can deduce that full blood count is highly clinically important for an effective management of lymphoid malignant patients on chemotherapy.

DOI: 10.7176/JMPB/61-04

Publication date: November 30^th 2019