Elevated Serum Level of DHEAS as a Hormone and IL-6 as a Proinflammatory Cytokine May Better Indicate Metabolic Syndrome in PCOS Women

Zozan Guleken, Huri Bulut, Pınar Yalçın Bahat, Sibel Yılmaz, Devrim Sarıbal


Polycystic ovarian syndrome (PCOS) is the most prevalent metabolic disorder in reproductive-age women, indeed multifactorial condition. Cytokines such as TNF-alpha and IL-6 have influence on several metabolic activities. The increase in dehydroepiandrosterone (DHEA) is thought to play an important role in IL-6-mediated pathogenetic effects in PCOS women. The aim of this study is to explore whether TNF-alpha and IL-6 are correlated hormone levels in PCOS disease.  We recruited 65 PCOS patients and 45 healthy controls. The serum IL-6, TNF-alpha, levels were measured by ELISA and clinical characteristics were measured. Both serum IL-6, TNF-alpha levels (p<0.01), or the serum TSH, FSH, LH, PRL levels were significantly higher in the patients of PCOS (p<0.01). Serum IL-6 levels were correlated with DHEAS level (r=-0.4186, p<0.01). DHEAS level tended to be higher in PCOS women with a correlation between age, BMI, IL-6 level and positively correlated with FSH, LH and PRL levels (p<0.01). There was an elevation of TSH level in the PCOS group (2.4±1.5) vs. control group (1.8±1.6). However, in control samples, there was no correlation between TNF alpha and IL-6, while in the PCOS samples positive correlation, was obtained. Oral glucose tolerance test (OGTT) was higher than the control (20.38±13.2) group vs. PCOS women (128.33±33.8) but only 3.44 % of them had Type II diabetes. HOMA-IR index was higher in the PCOS group (8.26±15.06) vs. control group (2.12±0.88) too. There was a correlation between age and IL-6 level and BMI. Serum IL-6 and DHEAS levels were significantly altered in PCOS patients and determined which might be PCOS prognostic importance.

Keywords; PCOS; Cytokines; TNF-alpha; IL-6; DHEAS; Metabolic syndrome

DOI: 10.7176/JMPB/71-02

Publication date:June 30th 2021

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