Role of Adipoq Rs 266729 Gene Polymorphism with Risk of Type 2 Diabetes Mellıtus: Case Control Study

Abstract

Objectıve: The aim of the study is to reveal the relationship between adiponection gene variants type 2 diabetes, in diabetes, which has become a majör problem in the twenty-first century.  Materıals and Methods: This case-control study included 100 patients (60 men and 40 women) with type 2 diabetes treated at Musayyib Hospital and 100 healthy volunteers of the same age and gender to serve as a control group for the study. In the study, DNA was extracted from blood and genotyped by PCR-RFLP and also clinical features of diabetes (Fasting glucose, HbA1c and Lipid profile) were investigated. Results: Compared to patients without diabetes, the frequency of the G allele of the rs266729 polymorphism was found to be significantly higher in diabetic participants. In addition, the homozygous GG genotype greatly increased the risk of Type II diabetes. Conclusıon: The heterozygous genotype (GC\CG) was associated with a twofold increased risk of type II diabetes compared to the wild type (CC), and although there was no significant difference in the clinical features of diabetes according to adiponectin genotypes, there was a significant difference in fasting glucose, HbA1c and lipid profile between patients and controls. In the Iraqi population, the adiponectin gene polymorphism rs266729 has been linked to Type II diabetes, with people with the heterozygous genotype (GC\CG) being significantly more likely to develop Type II diabetes.

Keywords: Adiponectin, Gene polymorphism, Type 2 diabetes,

DOI: 10.7176/JMPB/74-02

Publication date: January 31^st 2024