Erythropoietin and Anaemia in Patients with Chronic Renal Failure

Abstract

Hyporegenerative anaemia is common complication of chronic renal failure CRF and responsible for fatigue and reduced general  health condition among uremic patient. The main causes of anemia among patients with chronic renal failure are deficient production of erythropoietin (EPO), iron deficiency, and chronic disease with endogenous EPO resistance.

This study confirmed on patients with chronic renal failure in Merjan Teaching Hospital and highlighted on the relationship between anaemia and erythropoiten level. The estimation of hemoglobin among patients with CRF revealed that 55% of patients suffered from severe anaemia and 45%suffered from moderate anaemia      Erythropoiten level estimated by ELISA technique and mean and standard deviation of erythropoietin level among patients and control groups were12.2 uU/ml ± 2.6, 7.3uU/ml± 1.8 respectively and comparism mean of erythropoietin between patients and control group   was indicated that there is significant difference between two groups at p value< 0.05

By study the correlation between hemoglobin and erythropoietin revealed that there is inverses relation ship between hemoglobin and erythropoietin , we concluded from this study although the level of erythropoietin increase in patients with CRF but the level of erythropoietin are not enough foe correction of anaemia and patient may required for exogenous source for erythropoietin with iron supplement in management of anaemia

Keywords: erythropoiten Hyporegenerative anaemia