Effect of Interlukin-36 gamma and Tumor Necrosis Factor alpha on Patients with Polycystic Ovary Syndrome on Governorate Messan in Iraqifemale

Abstract

Background:Polycystic ovary syndrome PCOS is a heterogeneous disorder. PCOS affects 6–10% of women during their reproductive life.Its complete phenotype is manifested by ovulatory dysfunction, hyperandrogenism and polycystic ovaries.

Objective: The aim of this study is to evaluate a new recent member of the IL-1 super family of cytokinesinterleukin-36(IL-36) levels in serum that has a crucial roleindiagnosis diseasesand in order to evaluate its utility as a clinical biochemical parameter inPolycystic ovary syndrome.

Methods: The present study was conducted on 100 subjects which divided in to 4 groups. First group includes 25healthy individuals as control group . Second group includes 25 female with PCOS aspatient group newly diagnosis .Third group includes 25 patients with PCOS after 12 months from diagnosis. Fourth group also 25 patients after 24 months and more.  All subjects attendingfrom teaching AL-Sadder hospital and AL-Zahrawi hospital in  Governorate of  Messan in Iraq. Parametersmeasured in the sera of patient and healthy groups were interleukin-36 (IL-36), tumor necrosis factor alpha and ceruloplasmin concentration.

Results: A recent member of super family cytokines Interterleukin-36(IL-36) was determined in serum of polycystic ovary syndrome. Higher significant elevation was found when compared with healthy control.

Conclusion: From this study a conclusion was drawn, that evaluation of concentration of a new superfamilycytokines (IL-36) could be considered as clinical biochemical parameter in polycystic ovary syndrome  in Iraqifemale patients in Governorate of Missan. Also this study may demonstrated a relation between increased IL-36levels and increased TNF-? and ceruloplasmin levels.

Keywords: polycystic ovary syndrom, interleukin-36 (IL-36), cytokines, TNF-?,Ceruloplasmin