Expression of Emerging Novel Tumor markers in Oral Squamous cell carcinoma and their Clinical and Pathological correlation to determine the Prognosis and Usefulness as a Therapeutic target: A Systematic Review

Abstract

Background: Inspite of 1000s of novel tumor markers in past 2 decades there is not even a single tumor marker which is proved to have diagnostic or prognostic value in oral squamous cell carcinoma (OSCC). The purpose of this review is to examine the current status of the emerging novel tumor markers. Methods: This search strategy was in accordance with the Cochrane guidelines for systemic review. Articles were selected using Pubmed search. The article search included only those published in the English literature. Results: Total of 12 tumor markers were analyzed. None of the tumor markers analyzed has all the qualities for a tumor marker like good sensitivity, specificity for diagnosis or assessing the prognosis Conclusions: Thus far, studies, although inconclusive, have found that the likelihood of identifying a biomarker with such sensitivity and specificity may be slim, at least for the immediate future.

Key words: oral squamous cell carcinoma, novel tumor markers